Keychron has yet to provide a full spec sheet or product page for the G25 HE, but the mouse has been scanned and submitted to EloShapes for comparisons , where its specs and features are also available. The Keychron G25 HE measures in at 120 × 63 × 39 mm and weighs 46 g, which is on the lighter side for a wireless mouse, but not the lightest by any means. It is also a symmetrical shape with right-side programmable thumb buttons and a partially open bottom plate.

The G25 HE is powered by a PixArt PAW 3955 optical sensor and a Nordic 54LM20A MCU, which means it has a peak DPI of 40,000, up to 8 kHz polling rate, and can track at up to 750 IPS and 60 G of acceleration. The star of the show, and the mouse's namesake, are the MagOpt switches which feature both optical and Hall effect magnetic sensing, although the switches still have a click leaf and a distinct tactile bump, which has been largely considered to have a negative impact on the mouse's adjustable actuation trickery.